Cases
Focus on innovation to achieve quality
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Nanobody Discovery
Compared with conventional antibodies, nanobodies possess many unique advantages in expression and purification, stability, immunogenicity, and...
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AI-assisted Antibody Affinity Maturation/Modification
In recent years, with the launch of various antibody drugs, research on antibodies has become a hot topic in the biopharmaceutical field. Antibody...
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Development of CAR-T Drugs
Chimeric Antigen Receptor T-Cell Immunotherapy (CAR-T therapy) is an emerging cell-targeted therapy for treating tumors. It involves engineering T cells...
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Construction of a Human Antibody Library
The development of therapeutic monoclonal antibodies has gone through four stages: murine antibodies, human-murine chimeric antibodies, humanized antibodies, and fully human antibodies. Among them, the fragment antigen-binding region(Fab) and fragmen...
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The Construction of a "Three-hundred-billion Diversity" Antibody ...
The nature fully human antibody library constructed using phage display technology has an inherent disadvantage of low diversity (107 ~ 108), which reduces the success rate of antibody screening. The emergence of fully synthetic library technology ov...
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Antigen Structure Analysis and Preparation and Expression (AI Str...
With the development and maturity of antibody library construction technology, the high-size and high-diversity antibody library constructed by ABLINK is no longer a limiting factor in screening lead antibody molecules. However, the structure analysi...
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High-Affinity Antibody Screening
Antibody screening is a crucial step in developing monoclonal antibody drugs, bispecific antibody drugs, and cell therapies such as CAR-T. Identifying high-affinity and highly specific candidate antibodies greatly increases the likelihood of successf...
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Screening of Multi-pass Transmembrane Proteins
Multi-pass transmembrane proteins are protein molecules with hydrophobic transmembrane domains that traverse the cell membrane phospholipid bilayer and cross the intracellular and extracellular environments. They have diverse functions, and compared ...
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NGS-assisted High-Affinity Antibody Screening (AI Data Mining)
Next-generation sequencing (NGS), also known as high-throughput sequencing technology, is capable of sequencing hundreds of thousands to millions of nucleic acid molecules in a single run, compared to the traditional Sanger sequencing method. The dev...